Micromachined piconewton force sensor for biophysics investigations

by: Steven J Koch, Gayle E Thayer, Alex D Corwin, Maarten P de Boer

Applied Physics Letters, Vol. 89, No. 17. (2006)

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Abstract

We describe a micromachined force sensor that is able to measure forces as small as 1 pN in both air and water. First, we measured the force field produced by an electromagnet on individual 2.8 µm magnetic beads glued to the sensor. By repeating with 11 different beads, we measured a 9% standard deviation in saturation magnetization. We next demonstrated that the sensor was fully functional when immersed in physiological buffer. These results show that the force sensors can be useful for magnetic force calibration and also for measurement of biophysical forces on chip. ©2006 American Institute of Physics

@article{citeulike:1085854, abstract = {We describe a micromachined force sensor that is able to measure forces as small as 1\ \ pN in both air and water. First, we measured the force field produced by an electromagnet on individual 2.8\ \ \µm magnetic beads glued to the sensor. By repeating with 11 different beads, we measured a 9\% standard deviation in saturation magnetization. We next demonstrated that the sensor was fully functional when immersed in physiological buffer. These results show that the force sensors can be useful for magnetic force calibration and also for measurement of biophysical forces on chip. \©2006 American Institute of Physics}, author = {Koch, Steven J. and Thayer, Gayle E. and Corwin, Alex D. and de Boer, Maarten P. }, citeulike-article-id = {1085854}, doi = {10.1063/1.2364118}, journal = {Applied Physics Letters}, keywords = {beads, biomems, biophysics, electromagnet, force, magnetic, mems, micromachined, microspheres, sensor, summit}, number = {17}, posted-at = {2007-02-03 09:24:25}, priority = {0}, publisher = {AIP}, title = {Micromachined piconewton force sensor for biophysics investigations}, url = {http://scitation.aip.org/getabs/servlet/GetabsServlet?prog=normal\&id=APPLAB000089000017173901000001\&idtype=cvips\&gifs=yes}, volume = {89}, year = {2006} }

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TY - JOUR ID - citeulike:1085854 L3 - citeulike-article-id:1085854 TI - Micromachined piconewton force sensor for biophysics investigations JF - Applied Physics Letters VL - 89 IS - 17 PB - AIP N2 - We describe a micromachined force sensor that is able to measure forces as small as 1  pN in both air and water. First, we measured the force field produced by an electromagnet on individual 2.8  µm magnetic beads glued to the sensor. By repeating with 11 different beads, we measured a 9% standard deviation in saturation magnetization. We next demonstrated that the sensor was fully functional when immersed in physiological buffer. These results show that the force sensors can be useful for magnetic force calibration and also for measurement of biophysical forces on chip. ©2006 American Institute of Physics KW - beads KW - biomems KW - biophysics KW - electromagnet KW - force KW - magnetic KW - mems KW - micromachined KW - microspheres KW - sensor KW - summit AU - Koch, Steven AU - Thayer, Gayle AU - Corwin, Alex AU - de Boer, Maarten PY - 2006/// UR - http://scitation.aip.org/getabs/servlet/GetabsServlet?prog=normal&id=APPLAB000089000017173901000001&idtype=cvips&gifs=yes ER -

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