Conserved lipid-binding sites in membrane proteins: a focus on cytochrome c oxidase

@article{citeulike:2315351, abstract = {Specific interactions between lipids and membrane proteins have been observed in recent high-resolution crystal structures of membrane proteins. A number of cytochrome oxidase structures were analyzed, along with many amino acid sequences of membrane-spanning regions aligned according to their location in the membrane. The results reveal conservation of lipid-binding sites and of the residues that form them. These studies imply that bound lipids have important roles that are crucial to the assembly, structure, or activity of the protein. Evidence for some of these roles in subunit interactions, membrane insertion, and protein-protein complex formation is reviewed.}, author = {Qin, Ling and Sharpe, Martyn A. and Garavito, Michael R. and Ferguson-Miller, Shelagh }, booktitle = {Membranes / Engineering and design}, citeulike-article-id = {2315351}, doi = {10.1016/j.sbi.2007.07.001}, journal = {Current Opinion in Structural Biology}, keywords = {cytochrome, membranes, proteins}, month = {August}, number = {4}, pages = {444--450}, posted-at = {2008-01-31 15:57:31}, priority = {2}, title = {Conserved lipid-binding sites in membrane proteins: a focus on cytochrome c oxidase}, url = {http://dx.doi.org/10.1016/j.sbi.2007.07.001}, volume = {17}, year = {2007} }

TY - JOUR ID - citeulike:2315351 L3 - citeulike-article-id:2315351 TI - Conserved lipid-binding sites in membrane proteins: a focus on cytochrome c oxidase T2 - Membranes / Engineering and design JF - Current Opinion in Structural Biology VL - 17 IS - 4 SP - 444 EP - 450 N2 - Specific interactions between lipids and membrane proteins have been observed in recent high-resolution crystal structures of membrane proteins. A number of cytochrome oxidase structures were analyzed, along with many amino acid sequences of membrane-spanning regions aligned according to their location in the membrane. The results reveal conservation of lipid-binding sites and of the residues that form them. These studies imply that bound lipids have important roles that are crucial to the assembly, structure, or activity of the protein. Evidence for some of these roles in subunit interactions, membrane insertion, and protein-protein complex formation is reviewed. KW - cytochrome KW - membranes KW - proteins AU - Qin, Ling AU - Sharpe, Martyn AU - Garavito, Michael AU - Ferguson-Miller, Shelagh PY - 2007/08// UR - http://dx.doi.org/10.1016/j.sbi.2007.07.001 ER -