Domain Formation in the Plasma Membrane: Roles of Nonequilibrium Lipid Transport and Membrane Proteins

by: Jun Fan, Maria Sammalkorpi, Mikko Haataja

Physical Review Letters, Vol. 100, No. 17. (2008)

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Abstract

Compositional lipid domains (“lipid rafts”) in plasma membranes are believed to be important components of many cellular processes. The mechanisms by which cells regulate the sizes and lifetimes of these spatially extended domains are poorly understood at the moment. Here we show that the competition between phase separation in an immiscible lipid system and active cellular lipid transport processes naturally leads to the formation of such domains. Furthermore, we demonstrate that local interactions with immobile membrane proteins can spatially localize the rafts and lead to further clustering.

@article{citeulike:2811055, abstract = {Compositional lipid domains (\“lipid rafts\”) in plasma membranes are believed to be important components of many cellular processes. The mechanisms by which cells regulate the sizes and lifetimes of these spatially extended domains are poorly understood at the moment. Here we show that the competition between phase separation in an immiscible lipid system and active cellular lipid transport processes naturally leads to the formation of such domains. Furthermore, we demonstrate that local interactions with immobile membrane proteins can spatially localize the rafts and lead to further clustering.}, author = {Fan, Jun and Sammalkorpi, Maria and Haataja, Mikko }, citeulike-article-id = {2811055}, doi = {10.1103/PhysRevLett.100.178102}, journal = {Physical Review Letters}, keywords = {rafts}, number = {17}, posted-at = {2008-06-26 19:25:20}, priority = {2}, publisher = {APS}, title = {Domain Formation in the Plasma Membrane: Roles of Nonequilibrium Lipid Transport and Membrane Proteins}, url = {http://scitation.aip.org/getabs/servlet/GetabsServlet?prog=normal\&id=PRLTAO000100000017178102000001\&idtype=cvips\&gifs=yes}, volume = {100}, year = {2008} }

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TY - JOUR ID - citeulike:2811055 L3 - citeulike-article-id:2811055 TI - Domain Formation in the Plasma Membrane: Roles of Nonequilibrium Lipid Transport and Membrane Proteins JF - Physical Review Letters VL - 100 IS - 17 PB - APS N2 - Compositional lipid domains (“lipid rafts”) in plasma membranes are believed to be important components of many cellular processes. The mechanisms by which cells regulate the sizes and lifetimes of these spatially extended domains are poorly understood at the moment. Here we show that the competition between phase separation in an immiscible lipid system and active cellular lipid transport processes naturally leads to the formation of such domains. Furthermore, we demonstrate that local interactions with immobile membrane proteins can spatially localize the rafts and lead to further clustering. KW - rafts AU - Fan, Jun AU - Sammalkorpi, Maria AU - Haataja, Mikko PY - 2008/// UR - http://scitation.aip.org/getabs/servlet/GetabsServlet?prog=normal&id=PRLTAO000100000017178102000001&idtype=cvips&gifs=yes ER -

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