Nonequilibrium Raftlike Membrane Domains under Continuous Recycling

by: Matthew S Turner, Pierre Sens, Nicholas D Socci

Physical Review Letters, Vol. 95, No. 16. (2005)

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Abstract

We present a model for the kinetics of spontaneous membrane domain (raft) assembly that includes the effect of membrane recycling ubiquitous in living cells. We show that domains can have a broad power-law distribution with an average radius that scales with the 1/4 power of the domain lifetime when the line tension at the domain edges is large. For biologically reasonable recycling and diffusion rates, the average domain radius is in the tens of nm range, consistent with observations. This represents one possible link between signaling (involving rafts) and traffic (recycling) in cells. Finally, we present evidence that suggests that the average raft size may be the same for all scale-free recycling schemes.

@article{citeulike:2931921, abstract = {We present a model for the kinetics of spontaneous membrane domain (raft) assembly that includes the effect of membrane recycling ubiquitous in living cells. We show that domains can have a broad power-law distribution with an average radius that scales with the 1/4 power of the domain lifetime when the line tension at the domain edges is large. For biologically reasonable recycling and diffusion rates, the average domain radius is in the tens of nm range, consistent with observations. This represents one possible link between signaling (involving rafts) and traffic (recycling) in cells. Finally, we present evidence that suggests that the average raft size may be the same for all scale-free recycling schemes.}, author = {Turner, Matthew S. and Sens, Pierre and Socci, Nicholas D. }, citeulike-article-id = {2931921}, doi = {10.1103/PhysRevLett.95.168301}, journal = {Physical Review Letters}, keywords = {domains, rafts}, number = {16}, posted-at = {2008-06-26 19:36:00}, priority = {2}, publisher = {APS}, title = {Nonequilibrium Raftlike Membrane Domains under Continuous Recycling}, url = {http://scitation.aip.org/getabs/servlet/GetabsServlet?prog=normal\&id=PRLTAO000095000016168301000001\&idtype=cvips\&gifs=yes}, volume = {95}, year = {2005} }

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TY - JOUR ID - citeulike:2931921 L3 - citeulike-article-id:2931921 TI - Nonequilibrium Raftlike Membrane Domains under Continuous Recycling JF - Physical Review Letters VL - 95 IS - 16 PB - APS N2 - We present a model for the kinetics of spontaneous membrane domain (raft) assembly that includes the effect of membrane recycling ubiquitous in living cells. We show that domains can have a broad power-law distribution with an average radius that scales with the 1/4 power of the domain lifetime when the line tension at the domain edges is large. For biologically reasonable recycling and diffusion rates, the average domain radius is in the tens of nm range, consistent with observations. This represents one possible link between signaling (involving rafts) and traffic (recycling) in cells. Finally, we present evidence that suggests that the average raft size may be the same for all scale-free recycling schemes. KW - domains KW - rafts AU - Turner, Matthew AU - Sens, Pierre AU - Socci, Nicholas PY - 2005/// UR - http://scitation.aip.org/getabs/servlet/GetabsServlet?prog=normal&id=PRLTAO000095000016168301000001&idtype=cvips&gifs=yes ER -

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