Nanopore Formation and Phosphatidylserine Externalization in a Phospholipid Bilayer at High Transmembrane Potential.

@article{citeulike:683080, abstract = {Atomic-resolution molecular dynamics simulations of lipid bilayers containing 7\% phosphatidylserine (PS) on one leaflet are consistent with experimental observations of membrane poration and PS externalization in living cells exposed to nanosecond, megavolt-per-meter electric pulses. Nanometer-diameter aqueous pores develop within nanoseconds after application of an electric field of 450 mV/nm, and electrophoretic transport of the anionic PS headgroup along the newly constructed hydrophilic pore surface commences even while pore formation is still in progress.}, address = {Departments of Electrical Engineering and Chemical Engineering and Materials Science, Viterbi School of Engineering, University of Southern California, Los Angeles, California 90089-0271, MOSIS, Information Sciences Institute, Viterbi School of Engineering, University of Southern California, Marina del Rey, California 90292, and Department of Biological Sciences, University of Calgary, Calgary, Alberta, Canada T2N 1N4.}, author = {Vernier, P T. and Ziegler, Matthew J. and Sun, Yinghua and Chang, Wenji V. and Gundersen, Martin A. and Tieleman, D P. }, citeulike-article-id = {683080}, doi = {http://dx.doi.org/10.1021/ja0588306}, issn = {0002-7863}, journal = {J Am Chem Soc}, keywords = {translocation}, month = {May}, number = {19}, pages = {6288--6289}, posted-at = {2008-02-07 22:38:41}, priority = {2}, title = {Nanopore Formation and Phosphatidylserine Externalization in a Phospholipid Bilayer at High Transmembrane Potential.}, url = {http://dx.doi.org/10.1021/ja0588306}, volume = {128}, year = {2006} }

TY - JOUR ID - citeulike:683080 L3 - citeulike-article-id:683080 TI - Nanopore Formation and Phosphatidylserine Externalization in a Phospholipid Bilayer at High Transmembrane Potential. JF - J Am Chem Soc VL - 128 IS - 19 SP - 6288 EP - 6289 AD - Departments of Electrical Engineering and Chemical Engineering and Materials Science, Viterbi School of Engineering, University of Southern California, Los Angeles, California 90089-0271, MOSIS, Information Sciences Institute, Viterbi School of Engineering, University of Southern California, Marina del Rey, California 90292, and Department of Biological Sciences, University of Calgary, Calgary, Alberta, Canada T2N 1N4. SN - 0002-7863 N2 - Atomic-resolution molecular dynamics simulations of lipid bilayers containing 7% phosphatidylserine (PS) on one leaflet are consistent with experimental observations of membrane poration and PS externalization in living cells exposed to nanosecond, megavolt-per-meter electric pulses. Nanometer-diameter aqueous pores develop within nanoseconds after application of an electric field of 450 mV/nm, and electrophoretic transport of the anionic PS headgroup along the newly constructed hydrophilic pore surface commences even while pore formation is still in progress. KW - translocation AU - Vernier, P AU - Ziegler, Matthew AU - Sun, Yinghua AU - Chang, Wenji AU - Gundersen, Martin AU - Tieleman, D PY - 2006/05/17/ UR - http://dx.doi.org/10.1021/ja0588306 ER -