The Origins of Genome Architecture

@book{citeulike:1318668, abstract = {{With official genomic blueprints now available for hundreds of species, and thousands more expected in the near future, the field of biology has been forever transformed. Such readily accessible data have encouraged the proliferation of adaptive arguments for the evolution of gene and genomic features, often with little or no attention being given to simpler and more powerful alternative explanations. By integrating the central observations from molecular biology and population genetics relevant to comparative genomics, Lynch shows why the details matter. <P>Presented in a nontechnical fashion, at both the population-genetic and molecular-genetic levels, this book offers a unifying explanatory framework for how the peculiar architectural diversity of eukaryotic genomes and genes came to arise. Under Lynch's hypothesis, the genome-wide repatterning of eukaryotic gene structure, which resulted primarily from nonadaptive processes, provided an entirely novel resource from which natural selection could secondarily build new forms of organismal complexity.}}, author = {Lynch, Michael }, citeulike-article-id = {1318668}, comment = {I just bought it - he does a really good job explaining how neutral processes can generate the observed patterns in genomes. We need good null models before invoking adaptation as an explanation for perceived differences between genomes.}, howpublished = {Hardcover}, isbn = {0878934847}, keywords = {lab\_library}, month = {March}, posted-at = {2007-05-22 06:23:21}, priority = {0}, publisher = {{W.H. Freeman \& Company}}, title = {The Origins of Genome Architecture}, url = {http://www.amazon.ca/exec/obidos/redirect?tag=citeulike09-20\&amp;path=ASIN/0878934847}, year = {2007} }

TY - BOOK ID - citeulike:1318668 L3 - citeulike-article-id:1318668 TI - The Origins of Genome Architecture PB - {W.H. Freeman & Company} SN - 0878934847 N2 - {With official genomic blueprints now available for hundreds of species, and thousands more expected in the near future, the field of biology has been forever transformed. Such readily accessible data have encouraged the proliferation of adaptive arguments for the evolution of gene and genomic features, often with little or no attention being given to simpler and more powerful alternative explanations. By integrating the central observations from molecular biology and population genetics relevant to comparative genomics, Lynch shows why the details matter. <P>Presented in a nontechnical fashion, at both the population-genetic and molecular-genetic levels, this book offers a unifying explanatory framework for how the peculiar architectural diversity of eukaryotic genomes and genes came to arise. Under Lynch's hypothesis, the genome-wide repatterning of eukaryotic gene structure, which resulted primarily from nonadaptive processes, provided an entirely novel resource from which natural selection could secondarily build new forms of organismal complexity.} KW - lab_library N1 - I just bought it - he does a really good job explaining how neutral processes can generate the observed patterns in genomes. We need good null models before invoking adaptation as an explanation for perceived differences between genomes. AU - Lynch, Michael PY - 2007/03/30/ UR - http://www.amazon.ca/exec/obidos/redirect?tag=citeulike09-20&amp;path=ASIN/0878934847 ER -