Principles and applications of ultrasound backscatter microscopy

@article{citeulike:2625121, abstract = {The development of ultrasound backscatter microscopy (UBM) is described together with initial clinical and biological applications. UBM is essentially an extension of the powerful B-mode backscatter methods developed for clinical imaging in the 3-10-MHz frequency range. The development of new high sensitivity transducers in the 40-100-MHz range now permits visualization of tissue structures with resolution approaching 20 \μm and a maximum penetration of approximately 4 mm. The performance characteristics and trade-offs of these new polymer and ceramic devices are reviewed, and the implementation of high-frequency imaging systems is described. Initial clinical applications of UBM include ophthalmic, skin, and intravascular imaging. Examples of images and progress in these areas are presented. The biological application of UBM is illustrated by studies of drug uptake in living tumor spheroids. Significant increases in backscatter levels resulting from drugs targeting oxic and hypoxic cell populations are demonstrated}, author = {Foster, F. S. and Lockwood, G. R. and Ryan, L. K. and Harasiewicz, K. A. and Berube, L. and Rauth, A. M. }, booktitle = {Ultrasonics, Ferroelectrics and Frequency Control, IEEE Transactions on}, citeulike-article-id = {2625121}, doi = {http://dx.doi.org/10.1109/58.238115}, journal = {Ultrasonics, Ferroelectrics and Frequency Control, IEEE Transactions on}, keywords = {ubm}, number = {5}, pages = {608--617}, posted-at = {2008-04-03 06:03:11}, priority = {0}, title = {Principles and applications of ultrasound backscatter microscopy}, url = {http://dx.doi.org/10.1109/58.238115}, volume = {40}, year = {1993} }

TY - JOUR ID - citeulike:2625121 L3 - citeulike-article-id:2625121 TI - Principles and applications of ultrasound backscatter microscopy T2 - Ultrasonics, Ferroelectrics and Frequency Control, IEEE Transactions on JF - Ultrasonics, Ferroelectrics and Frequency Control, IEEE Transactions on VL - 40 IS - 5 SP - 608 EP - 617 N2 - The development of ultrasound backscatter microscopy (UBM) is described together with initial clinical and biological applications. UBM is essentially an extension of the powerful B-mode backscatter methods developed for clinical imaging in the 3-10-MHz frequency range. The development of new high sensitivity transducers in the 40-100-MHz range now permits visualization of tissue structures with resolution approaching 20 μm and a maximum penetration of approximately 4 mm. The performance characteristics and trade-offs of these new polymer and ceramic devices are reviewed, and the implementation of high-frequency imaging systems is described. Initial clinical applications of UBM include ophthalmic, skin, and intravascular imaging. Examples of images and progress in these areas are presented. The biological application of UBM is illustrated by studies of drug uptake in living tumor spheroids. Significant increases in backscatter levels resulting from drugs targeting oxic and hypoxic cell populations are demonstrated KW - ubm AU - Foster, FS AU - Lockwood, GR AU - Ryan, LK AU - Harasiewicz, KA AU - Berube, L AU - Rauth, AM PY - 1993/// UR - http://dx.doi.org/10.1109/58.238115 ER -