Comparative genomic hybridization.

@article{citeulike:1139297, abstract = {Altering DNA copy number is one of the many ways that gene expression and function may be modified. Some variations are found among normal individuals ( 14, 35, 103 ), others occur in the course of normal processes in some species ( 33 ), and still others participate in causing various disease states. For example, many defects in human development are due to gains and losses of chromosomes and chromosomal segments that occur prior to or shortly after fertilization, whereas DNA dosage alterations that occur in somatic cells are frequent contributors to cancer. Detecting these aberrations, and interpreting them within the context of broader knowledge, facilitates identification of critical genes and pathways involved in biological processes and diseases, and provides clinically relevant information. Over the past several years array comparative genomic hybridization (array CGH) has demonstrated its value for analyzing DNA copy number variations. In this review we discuss the state of the art of array CGH and its applications in medical genetics and cancer, emphasizing general concepts rather than specific results.}, address = {Comprehensive Cancer Center, Department of Laboratory Medicine, University of California, San Francisco, California 94143, USA. pinkel@cc.ucsf.edu}, author = {Pinkel, D. and Albertson, D. G. }, citeulike-article-id = {1139297}, comment = {Altering DNA copy number is one of the many ways that gene expression and function may be modified. Some variations are found among normal individuals ( 14, 35, 103 ), others occur in the course of normal processes in some species ( 33 ), and still others participate in causing various disease states. For example, many defects in human development are due to gains and losses of chromosomes and chromosomal segments that occur prior to or shortly after fertilization, whereas DNA dosage alterations that occur in somatic cells are frequent contributors to cancer. Detecting these aberrations, and interpreting them within the context of broader knowledge, facilitates identification of critical genes and pathways involved in biological processes and diseases, and provides clinically relevant information. Over the past several years array comparative genomic hybridization (array CGH) has demonstrated its value for analyzing DNA copy number variations. In this review we discuss the state of the art of array CGH and its applications in medical genetics and cancer, emphasizing general concepts rather than specific results.}, doi = {10.1146/annurev.genom.6.080604.162140}, issn = {1527-8204}, journal = {Annu Rev Genomics Hum Genet}, keywords = {array, cgh, review}, pages = {331--354}, posted-at = {2007-03-04 05:34:03}, priority = {2}, title = {Comparative genomic hybridization.}, url = {http://dx.doi.org/10.1146/annurev.genom.6.080604.162140}, volume = {6}, year = {2005} }

TY - JOUR ID - citeulike:1139297 L3 - citeulike-article-id:1139297 TI - Comparative genomic hybridization. JF - Annu Rev Genomics Hum Genet VL - 6 SP - 331 EP - 354 AD - Comprehensive Cancer Center, Department of Laboratory Medicine, University of California, San Francisco, California 94143, USA. pinkel@cc.ucsf.edu SN - 1527-8204 N2 - Altering DNA copy number is one of the many ways that gene expression and function may be modified. Some variations are found among normal individuals ( 14, 35, 103 ), others occur in the course of normal processes in some species ( 33 ), and still others participate in causing various disease states. For example, many defects in human development are due to gains and losses of chromosomes and chromosomal segments that occur prior to or shortly after fertilization, whereas DNA dosage alterations that occur in somatic cells are frequent contributors to cancer. Detecting these aberrations, and interpreting them within the context of broader knowledge, facilitates identification of critical genes and pathways involved in biological processes and diseases, and provides clinically relevant information. Over the past several years array comparative genomic hybridization (array CGH) has demonstrated its value for analyzing DNA copy number variations. In this review we discuss the state of the art of array CGH and its applications in medical genetics and cancer, emphasizing general concepts rather than specific results. KW - array KW - cgh KW - review N1 - Altering DNA copy number is one of the many ways that gene expression and function may be modified. Some variations are found among normal individuals ( 14, 35, 103 ), others occur in the course of normal processes in some species ( 33 ), and still others participate in causing various disease states. For example, many defects in human development are due to gains and losses of chromosomes and chromosomal segments that occur prior to or shortly after fertilization, whereas DNA dosage alterations that occur in somatic cells are frequent contributors to cancer. Detecting these aberrations, and interpreting them within the context of broader knowledge, facilitates identification of critical genes and pathways involved in biological processes and diseases, and provides clinically relevant information. Over the past several years array comparative genomic hybridization (array CGH) has demonstrated its value for analyzing DNA copy number variations. In this review we discuss the state of the art of array CGH and its applications in medical genetics and cancer, emphasizing general concepts rather than specific results. AU - Pinkel, D AU - Albertson, DG PY - 2005/// UR - http://dx.doi.org/10.1146/annurev.genom.6.080604.162140 ER -