Effect of stretch on contraction and the Ca2+ transient in ferret ventricular muscles during hypoxia and acidosis.

@article{citeulike:694092, abstract = {The effect of stretch on cardiac muscle contraction and the Ca2+ transient was studied during hypoxia and acidosis in isolated ferret ventricular muscles. In control conditions, a maintained stretch produced an immediate increase in tension followed by a slow increase in tension and the Ca2+ transient. A stretch between contractions (diastolic stretch) caused only a slow increase in tension and the Ca2+ transient, whereas a stretch during the period of contraction (systolic stretch) produced an immediate increase in tension followed by a small slow increase in tension and the Ca2+ transient. In hypoxia, the immediate percent increase in tension was the same as in control. However, the slow increase was smaller during all three types of stretch. In acidosis, the immediate percent increase in tension was larger than in control. The slow change was the same during maintained stretch. However, the slow increase in tension was smaller during diastolic stretch and larger during systolic stretch. Thus the stretch-dependent increase in contraction is inhibited during hypoxia and modulated by acidosis.}, address = {Department of Physiology, University of Leeds, United Kingdom.}, author = {Hongo, K. and White, E. and Orchard, C. H. }, citeulike-article-id = {694092}, issn = {0002-9513}, journal = {Am J Physiol}, keywords = {force, hypoxia}, month = {September}, number = {3 Pt 1}, posted-at = {2006-06-13 01:06:34}, priority = {5}, title = {Effect of stretch on contraction and the Ca2+ transient in ferret ventricular muscles during hypoxia and acidosis.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/7573399}, volume = {269}, year = {1995} }

TY - JOUR ID - citeulike:694092 L3 - citeulike-article-id:694092 TI - Effect of stretch on contraction and the Ca2+ transient in ferret ventricular muscles during hypoxia and acidosis. JF - Am J Physiol VL - 269 IS - 3 Pt 1 AD - Department of Physiology, University of Leeds, United Kingdom. SN - 0002-9513 N2 - The effect of stretch on cardiac muscle contraction and the Ca2+ transient was studied during hypoxia and acidosis in isolated ferret ventricular muscles. In control conditions, a maintained stretch produced an immediate increase in tension followed by a slow increase in tension and the Ca2+ transient. A stretch between contractions (diastolic stretch) caused only a slow increase in tension and the Ca2+ transient, whereas a stretch during the period of contraction (systolic stretch) produced an immediate increase in tension followed by a small slow increase in tension and the Ca2+ transient. In hypoxia, the immediate percent increase in tension was the same as in control. However, the slow increase was smaller during all three types of stretch. In acidosis, the immediate percent increase in tension was larger than in control. The slow change was the same during maintained stretch. However, the slow increase in tension was smaller during diastolic stretch and larger during systolic stretch. Thus the stretch-dependent increase in contraction is inhibited during hypoxia and modulated by acidosis. KW - force KW - hypoxia AU - Hongo, K AU - White, E AU - Orchard, CH PY - 1995/09// UR - http://view.ncbi.nlm.nih.gov/pubmed/7573399 ER -