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xdeupis b2ar [48 articles]

Artikler nylig sendt til xdeupis bibliotek klassifisert med nøkkelordet b2ar. You can also see everyone's b2ar.
  • Crystallizing thinking about the beta2-adrenergic receptor.
    Mol Pharmacol (31 January 2008)
    by Arun K K Shukla, Jin-Peng P Sun, Robert J J Lefkowitz
    posted to review gpcr crystallography b2ar by xdeupi on 2008-05-13 16:09:07 as ** along with 2 people merj tkershaw
  • Clinical consequences of ADR2 polymorphisms
    Pharmacogenomics, Vol. 9, No. 3. (March 2008), pp. 349-358.
    by Hawkins, A Gregory, Weiss, T Scott, Bleecker, R Eugene
    posted to review polymorphism pharmacology genome drug disease b2ar by xdeupi on 2008-05-03 17:12:39 as **
  • beta-Arrestin-biased Agonism at the beta2-Adrenergic Receptor.
    J Biol Chem, Vol. 283, No. 9. (29 February 2008), pp. 5669-5676.
    by MT Drake, JD Violin, EJ Whalen, JW Wisler, SK Shenoy, RJ Lefkowitz
    posted to activation agonist arrestin b2ar biased_agonism drug gproteins imaging internalization ligands pharmacology by xdeupi on 2008-02-27 10:39:07 as *** along with 1 group LabCompMed
  • G-protein-coupled receptor signalling through protein networks.
    Biochem Soc Trans, Vol. 35, No. Pt 1. (February 2007), pp. 23-27.
    by AD Strosberg, C Nahmias
    posted to b2ar gpcr pharmacology review structure by xdeupi on 2007-06-29 21:10:57 as ** along with 1 group LabCompMed
  • G protein coupled receptor structure and activation.
    Biochim Biophys Acta, Vol. 1768, No. 4. (April 2007), pp. 794-807.
    by BK Kobilka
    posted to activation b2ar gpcr review switch by xdeupi on 2007-06-02 19:19:32 as ** along with 4 people and 2 groups jyuh Fritz merj adamsdi neurolit LabCompMed
  • A monomeric G protein-coupled receptor isolated in a high-density lipoprotein particle efficiently activates its G protein.
    Proc Natl Acad Sci U S A (23 April 2007)
    by Matthew R R Whorton, Michael P P Bokoch, Søren G F G Rasmussen, Bo Huang, Richard N N Zare, Brian Kobilka, Roger K K Sunahara
    posted to activation b2ar dimer by xdeupi on 2007-05-02 09:04:56 as ** along with 1 group LabCompMed
  • Role of group-conserved residues in the helical core of beta2-adrenergic receptor.
    Proc Natl Acad Sci U S A, Vol. 104, No. 17. (24 April 2007), pp. 7027-7032.
    by P Chelikani, V Hornak, M Eilers, PJ Reeves, SO Smith, UL Rajbhandary, HG Khorana
    posted to activation agonist b2ar ser switch tm4 by xdeupi on 2007-04-26 12:27:17 as ** along with 1 group LabCompMed
  • Bioluminescence resonance energy transfer as a screening assay: Focus on partial and inverse agonism.
    J Biomol Screen, Vol. 12, No. 1. (February 2007), pp. 41-49.
    by L Elster, C Elling, A Heding
    posted to activation agonist b2ar fret ligands by xdeupi on 2007-04-10 18:50:15 as ** along with 1 group LabCompMed
  • Structure and conformational changes in the C-terminal domain of the beta 2-adrenoceptor: Insights from fluorescence resonance energy tranfer studies.
    J Biol Chem (8 March 2007)
    by Sebastien Granier, Samuel Kim, Aaron M M Shafer, Venkata R P R Ratnala, Juan J J Fung, Richard N N Zare, Brian K K Kobilka
    posted to activation b2ar cterm dynamics fret structure by xdeupi on 2007-03-21 11:39:56 as ** along with 1 group LabCompMed
  • Dosage-dependent switch from G protein-coupled to G protein-independent signaling by a GPCR
    The EMBO Journal, Vol. aop, No. current. (14 December 2006)
    by Yutong Sun, Jianyun Huang, Yang Xiang, Murat Bastepe, Harald Juppner, Brian K Kobilka, Jillian J Zhang, Xin-Yun Huang
    posted to activation b2ar drug pharmacology switch by xdeupi on 2007-03-21 11:13:23 as ** along with 1 person and 1 group Guff32 LabCompMed
  • notes Real-time optical recording of beta1-adrenergic receptor activation reveals supersensitivity of the Arg389 variant to carvedilol.
    J Clin Invest, Vol. 117, No. 1. (January 2007), pp. 229-235.
    by F Rochais, JP Vilardaga, VO Nikolaev, M Bünemann, MJ Lohse, S Engelhardt
    posted to activation agonist b2ar helix8 mutation by xdeupi on 2007-03-12 14:39:00 as ***** along with 1 group LabCompMed
  • Subclassification and nomenclature of alpha- and beta-adrenoceptors.
    Curr Top Med Chem, Vol. 7, No. 2. (2007), pp. 129-134.
    by JP Hieble
    posted to agonist b2ar drug genome ligands pharmacology review by xdeupi on 2007-03-12 14:33:19 as ** along with 1 group LabCompMed
  • Recent advances in identification and characterization of beta-adrenoceptor agonists and antagonists.
    Curr Top Med Chem, Vol. 7, No. 2. (2007), pp. 207-216.
    by JP Hieble
    posted to agonist b2ar drug ligands pharmacology by xdeupi on 2007-03-12 14:32:04 as ** along with 1 group LabCompMed
  • Organization of beta-adrenoceptor signaling compartments by sympathetic innervation of cardiac myocytes.
    J Cell Biol, Vol. 176, No. 4. (12 February 2007), pp. 521-533.
    by OG Shcherbakova, CM Hurt, Y Xiang, ML Dell'acqua, Q Zhang, RW Tsien, BK Kobilka
    posted to b2ar imaging by xdeupi on 2007-02-20 10:06:46 as ** along with 1 group LabCompMed
  • Both Ligand- and Cell-Specific Parameters Control Ligand Agonism in a Kinetic Model of G Protein-Coupled Receptor Signaling.
    PLoS Comput Biol, Vol. 3, No. 1. (12 January 2007)
    by Tamara L L Kinzer-Ursem, Jennifer J J Linderman
    posted to activation agonist b2ar pharmacology by xdeupi on 2007-02-13 15:38:17 as **** along with 1 group LabCompMed
  • The Cationminus signpi Interaction.
    Chem Rev, Vol. 97, No. 5. (5 August 1997), pp. 1303-1324.
    by Jennifer C Ma, Dennis A Dougherty
    posted to trp ligands histamine cation-pi binding b2ar by xdeupi on 2007-01-11 14:28:54 as ** along with 1 group LabCompMed
  • dummy
    by Dummy
    posted to 5ht1a activation agonist amber amine arrestin b2ar bimane binding cam ccr5 channel chemokine chimera crystallography cterm cxcr1 d250 dimer disease drug dry dynamics ecl2 evolution expression fluorescence folding fret genome gly gpcr gproteins hbond helix helix8 histamine hormone icl3 imaging internalization ionic leukotriene lhr ligands lipids lock loops md membrane modeling mutation n745 n749 nmr no-tag npxxy nterm opioid pharmacology polymorphism pro-kink protonation review rhodopsin s542 sequence ser spin_labeling structure switch test thr thyrotropin tm2 tm3 tm5 tm6 tm7 toggle transmembrane trp txp w648 by xdeupi on 2006-10-30 12:30:16 as ** along with 2 people and 1 group jessicaopacic ivanrt LabCompMed
  • Modeling and active site refinement for G protein-coupled receptors: application to the beta-2 adrenergic receptor.
    J Comput Aided Mol Des (13 October 2006)
    by Stanley R Krystek, S R Kimura, Andrew J Tebben
    posted to b2ar binding drug ligands modeling pharmacology by xdeupi on 2006-10-27 09:43:03 as ** along with 1 person and 1 group daevans LabCompMed
  • GRK specificity for beta -arrestin recruitment to the beta 2-adrenergic receptor revealed by fluorescence resonance energy transfer.
    J Biol Chem (10 May 2006)
    by Jonathan D D Violin, Xiu-Rong R Ren, Robert J J Lefkowitz
    posted to arrestin b2ar fret gpcr by xdeupi on 2006-09-23 11:20:25 as *** along with 1 person and 1 group tkershaw LabCompMed
  • Functional selectivity and classical concepts of quantitative pharmacology.
    J Pharmacol Exp Ther (27 June 2006)
    by Jonathan D D Urban, William P P Clarke, Mark von Zastrow, David E E Nichols, Brian K K Kobilka, Harel Weinstein, Jonathan A A Javitch, Bryan L L Roth, Arthur Christopoulos, Patrick Sexton, Keith Miller, Michael Spedding, Richard B B Mailman
    posted to activation b2ar pharmacology review switch by xdeupi on 2006-09-07 15:43:50 as ***** along with 1 person and 1 group kentsis LabCompMed
  • Coupling ligand structure to specific conformational switches in the [beta]2-adrenoceptor
    Nat Chem Biol, Vol. 2, No. 8. (2006), pp. 417-422.
    by Xiaojie Yao, Charles Parnot, Xavier Deupi, Venkata R Ratnala, Gayathri Swaminath, David Farrens, Brian Kobilka
    posted to activation b2ar bimane lock by xdeupi on 2006-09-07 14:39:58 as ** along with 1 person and 1 group lechristophe LabCompMed
  • A polymorphism within a conserved beta(1)-adrenergic receptor motif alters cardiac function and beta-blocker response in human heart failure.
    Proc Natl Acad Sci U S A, Vol. 103, No. 30. (25 July 2006), pp. 11288-11293.
    by SB Liggett, J Mialet-Perez, S Thaneemit-Chen, SA Weber, SM Greene, D Hodne, B Nelson, J Morrison, MJ Domanski, LE Wagoner, WT Abraham, JL Anderson, JF Carlquist, HJ Krause-Steinrauf, LC Lazzeroni, JD Port, PW Lavori, MR Bristow
    posted to b2ar disease drug genome helix8 ligands polymorphism by xdeupi on 2006-09-05 11:38:25 as ** along with 1 group LabCompMed
  • Novel mutants of the human beta1-adrenergic receptor reveal amino acids relevant for receptor activation.
    J Biol Chem, Vol. 281, No. 26. (30 June 2006), pp. 18120-18125.
    by B Behr, C Hoffmann, G Ottolina, KN Klotz
    posted to activation agonist b2ar binding drug ligands modeling mutation pharmacology structure by xdeupi on 2006-09-05 11:05:20 as *** along with 1 group LabCompMed
  • The three-dimensional structure of the N-terminal domain of corticotropin-releasing factor receptors: sushi domains and the B1 family of G protein-coupled receptors.
    Ann N Y Acad Sci, Vol. 1070 (July 2006), pp. 105-119.
    by MH Perrin, CR Grace, R Riek, WW Vale
    posted to b2ar nterm structure by xdeupi on 2006-09-05 10:22:30 as ** along with 1 group LabCompMed
  • Metal Ion Site Engineering Indicates a Global Toggle Switch Model for Seven-transmembrane Receptor Activation.
    J Biol Chem, Vol. 281, No. 25. (23 June 2006), pp. 17337-17346.
    by CE Elling, TM Frimurer, LO Gerlach, R Jorgensen, B Holst, TW Schwartz
    posted to activation b2ar modeling pro-kink structure switch toggle transmembrane by xdeupi on 2006-07-04 12:17:13 as read along with 1 person and 1 group IrinaMoreira LabCompMed
  • Changes in interhelical hydrogen bonding upon rhodopsin activation.
    J Mol Biol, Vol. 347, No. 4. (8 April 2005), pp. 803-812.
    by AB Patel, E Crocker, PJ Reeves, EV Getmanova, M Eilers, HG Khorana, SO Smith
    posted to activation b2ar binding hbond helix ligands nmr pro-kink rhodopsin ser structure switch tm5 tm6 toggle by xdeupi on 2006-06-01 13:51:11 as read along with 1 group LabCompMed
  • Toward the active conformations of rhodopsin and the beta2-adrenergic receptor.
    Proteins, Vol. 56, No. 1. (1 July 2004), pp. 67-84.
    by PR Gouldson, NJ Kidley, RP Bywater, G Psaroudakis, HD Brooks, C Diaz, D Shire, CA Reynolds
    posted to activation b2ar modeling rhodopsin structure by xdeupi on 2006-03-08 14:57:08 as ** along with 1 group LabCompMed
  • Molecular evolution of adrenoceptors and dopamine receptors: implications for the binding of catecholamines.
    J Med Chem, Vol. 49, No. 5. (9 March 2006), pp. 1706-1719.
    by H Xhaard, VV Rantanen, T Nyrönen, MS Johnson
    posted to agonist b2ar binding gpcr ligands modeling by xdeupi on 2006-03-06 10:11:30 as **** along with 1 group LabCompMed
  • Molecular mechanisms of beta2-adrenergic receptor function and regulation.
    Proc Am Thorac Soc, Vol. 2, No. 4. (2005)
    by DW McGraw, SB Liggett
    posted to activation agonist b2ar by xdeupi on 2006-02-20 09:27:39 as *** along with 1 group LabCompMed
  • Imaging nanometer domains of beta-adrenergic receptor complexes on the surface of cardiac myocytes.
    Nat Chem Biol, Vol. 1, No. 4. (September 2005), pp. 196-202.
    by A Ianoul, DD Grant, Y Rouleau, M Bani-Yaghoub, LJ Johnston, JP Pezacki
    posted to b2ar fluorescence imaging by xdeupi on 2006-02-13 15:59:57 as ** along with 1 group LabCompMed
  • Functional domains of the mouse beta3-adrenoceptor associated with differential G protein coupling.
    J Pharmacol Exp Ther, Vol. 315, No. 3. (December 2005), pp. 1354-1361.
    by M Sato, DS Hutchinson, T Bengtsson, A Floren, U Langel, T Horinouchi, BA Evans, RJ Summers
    posted to activation b2ar gproteins by xdeupi on 2006-01-30 09:22:20 as ** along with 1 group LabCompMed
  • beta-Arrestin-dependent, G Protein-independent ERK1/2 Activation by the beta2 Adrenergic Receptor
    J. Biol. Chem., Vol. 281, No. 2. (13 January 2006), pp. 1261-1273.
    by Sudha K Shenoy, Matthew T Drake, Christopher D Nelson, Daniel A Houtz, Kunhong Xiao, Srinivasan Madabushi, Eric Reiter, Richard T Premont, Olivier Lichtarge, Robert J Lefkowitz
    posted to activation arrestin b2ar by xdeupi on 2006-01-11 11:33:08 as ** along with 1 group LabCompMed
  • Beta2-adrenoceptor gene polymorphisms.
    Pharmacogenet Genomics, Vol. 15, No. 5. (May 2005), pp. 267-275.
    by OE Brodde, K Leineweber
    posted to b2ar polymorphism by xdeupi on 2006-01-11 11:26:48 as ** along with 1 group LabCompMed
  • Functionally different agonists induce distinct conformations in the G protein coupling domain of the beta 2 adrenergic receptor.
    J Biol Chem, Vol. 276, No. 27. (6 July 2001), pp. 24433-24436.
    by P Ghanouni, Z Gryczynski, JJ Steenhuis, TW Lee, DL Farrens, JR Lakowicz, BK Kobilka
    posted to activation agonist b2ar by xdeupi on 2005-12-16 10:23:33 as read along with 1 group LabCompMed
  • Agonist-induced conformational changes in the G-protein-coupling domain of the beta 2 adrenergic receptor.
    Proc Natl Acad Sci U S A, Vol. 98, No. 11. (22 May 2001), pp. 5997-6002.
    by P Ghanouni, JJ Steenhuis, DL Farrens, BK Kobilka
    posted to activation agonist b2ar fluorescence by xdeupi on 2005-12-16 10:22:41 as ** along with 1 group LabCompMed
  • Single-molecule spectroscopy of the beta(2) adrenergic receptor: observation of conformational substates in a membrane protein.
    Proc Natl Acad Sci U S A, Vol. 98, No. 15. (17 July 2001), pp. 8469-8474.
    by G Peleg, P Ghanouni, BK Kobilka, RN Zare
    posted to activation agonist b2ar by xdeupi on 2005-12-16 10:21:35 as read along with 1 person and 2 groups yanjiang LabCompMed moernerlab
  • Sequential binding of agonists to the beta2 adrenoceptor. Kinetic evidence for intermediate conformational states.
    J Biol Chem, Vol. 279, No. 1. (2 January 2004), pp. 686-691.
    by G Swaminath, Y Xiang, TW Lee, J Steenhuis, C Parnot, BK Kobilka
    posted to activation agonist b2ar binding ligands tm6 by xdeupi on 2005-12-16 10:19:18 as read along with 1 person and 1 group jddowney LabCompMed
  • Mechanisms of disease: beta-adrenergic receptors--alterations in signal transduction and pharmacogenomics in heart failure.
    Nat Clin Pract Cardiovasc Med, Vol. 2, No. 9. (September 2005), pp. 475-483.
    by DS Feldman, CA Carnes, WT Abraham, MR Bristow
    posted to b2ar disease by xdeupi on 2005-11-04 22:01:30 as ** along with 1 group LabCompMed
  • Agonist binding: a multistep process.
    Mol Pharmacol, Vol. 65, No. 5. (May 2004), pp. 1060-1062.
    by B Kobilka
    posted to activation agonist b2ar binding gpcr by xdeupi on 2005-11-02 22:50:37 as ** along with 1 group LabCompMed
  • notes The forgotten serine. A critical role for Ser-2035.42 in ligand binding to and activation of the beta 2-adrenergic receptor.
    J Biol Chem, Vol. 275, No. 48. (1 December 2000), pp. 37779-37788.
    by G Liapakis, JA Ballesteros, S Papachristou, WC Chan, X Chen, JA Javitch
    posted to activation agonist b2ar binding s542 ser tm5 by xdeupi on 2005-11-01 01:02:07 as ** along with 1 group LabCompMed
  • Activation of the beta 2-adrenergic receptor involves disruption of an ionic lock between the cytoplasmic ends of transmembrane segments 3 and 6.
    J Biol Chem, Vol. 276, No. 31. (3 August 2001), pp. 29171-29177.
    by JA Ballesteros, AD Jensen, G Liapakis, SG Rasmussen, L Shi, U Gether, JA Javitch
    posted to activation b2ar gpcr helix ionic lock pro-kink switch tm3 tm6 by xdeupi on 2005-11-01 00:58:31 as ** along with 1 person and 1 group IrinaMoreira LabCompMed
  • Synergistic contributions of the functional groups of epinephrine to its affinity and efficacy at the beta2 adrenergic receptor.
    Mol Pharmacol, Vol. 65, No. 5. (May 2004), pp. 1181-1190.
    by G Liapakis, WC Chan, M Papadokostaki, JA Javitch
    posted to activation agonist b2ar by xdeupi on 2005-11-01 00:57:14 as read along with 1 group LabCompMed
  • Catechol-binding serines of beta(2)-adrenergic receptors control the equilibrium between active and inactive receptor states.
    Mol Pharmacol, Vol. 57, No. 1. (January 2000), pp. 198-210.
    by C Ambrosio, P Molinari, S Cotecchia, T Costa
    posted to activation agonist b2ar ser tm5 by xdeupi on 2005-10-31 23:56:50 as read along with 1 group LabCompMed
  • Mutations inducing divergent shifts of constitutive activity reveal different modes of binding among catecholamine analogues to the beta(2)-adrenergic receptor.
    Br J Pharmacol, Vol. 135, No. 7. (April 2002), pp. 1715-1722.
    by R Del Carmine, C Ambrosio, M Sbraccia, S Cotecchia, AP Ijzerman, T Costa
    posted to activation agonist b2ar by xdeupi on 2005-10-31 23:55:27 as **** along with 1 group LabCompMed
  • "Induced-fit" mechanism for catecholamine binding to the beta2-adrenergic receptor.
    Mol Pharmacol, Vol. 66, No. 2. (August 2004), pp. 356-363.
    by R Del Carmine, P Molinari, M Sbraccia, C Ambrosio, T Costa
    posted to activation agonist b2ar by xdeupi on 2005-10-31 23:54:36 as ** along with 1 group LabCompMed
  • Different structural requirements for the constitutive and the agonist-induced activities of the beta2-adrenergic receptor.
    J Biol Chem, Vol. 280, No. 25. (24 June 2005), pp. 23464-23474.
    by C Ambrosio, P Molinari, F Fanelli, Y Chuman, M Sbraccia, O Ugur, T Costa
    posted to activation agonist b2ar ser by xdeupi on 2005-10-31 23:54:01 as ***** along with 1 group LabCompMed
  • Beta2 adrenergic receptor activation. Modulation of the proline kink in transmembrane 6 by a rotamer toggle switch.
    J Biol Chem, Vol. 277, No. 43. (25 October 2002), pp. 40989-40996.
    by L Shi, G Liapakis, R Xu, F Guarnieri, JA Ballesteros, JA Javitch
    posted to activation b2ar pro-kink switch tm6 toggle w648 by xdeupi on 2005-10-28 05:04:25 as read along with 1 person and 1 group IrinaMoreira LabCompMed
  • Probing the beta2 adrenoceptor binding site with catechol reveals differences in binding and activation by agonists and partial agonists.
    J Biol Chem, Vol. 280, No. 23. (10 June 2005), pp. 22165-22171.
    by G Swaminath, X Deupi, TW Lee, W Zhu, FS Thian, TS Kobilka, B Kobilka
    posted to activation agonist b2ar switch toggle by xdeupi on 2005-10-25 01:25:28 as read along with 1 person and 3 groups marcius BioinfoCIPF LabCompMed SGU-CIPF
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