Recent advances in iron oxide nanocrystal technology for medical imaging

@article{citeulike:1530000, abstract = {Superparamagnetic iron oxide particles (SPIO and USPIO) have a variety of applications in molecular and cellular imaging. Most of the recent research has concerned cellular imaging with imaging of in vivo macrophage activity. According to the iron oxide nanoparticle composition and size which influence their biodistribution, several clinical applications are possible: detection liver metastases, metastatic lymph nodes, inflammatory and/or degenerative diseases. USPIO are investigated as blood pool agents with T1 weighted sequence for angiography, tumour permeability and tumour blood volume or steady-state cerebral blood volume and vessel size index measurements using T2* weighted sequences. Stem cell migration and immune cell trafficking, as well as targeted iron oxide nanoparticles for molecular imaging studies, are at the stage of proof of concept, mainly in animal models.}, author = {Corot, Claire and Robert, Philippe and Idee, Jean-Marc and Port, Marc }, booktitle = {Particulate Nanomedicines}, citeulike-article-id = {1530000}, doi = {http://dx.doi.org/10.1016/j.addr.2006.09.013}, journal = {Advanced Drug Delivery Reviews}, keywords = {molecular-imaging, mri, spio, uspio}, month = {December}, number = {14}, pages = {1471--1504}, posted-at = {2007-08-02 09:55:31}, priority = {5}, title = {Recent advances in iron oxide nanocrystal technology for medical imaging}, url = {http://dx.doi.org/10.1016/j.addr.2006.09.013}, volume = {58}, year = {2006} }

TY - JOUR ID - citeulike:1530000 L3 - citeulike-article-id:1530000 TI - Recent advances in iron oxide nanocrystal technology for medical imaging T2 - Particulate Nanomedicines JF - Advanced Drug Delivery Reviews VL - 58 IS - 14 SP - 1471 EP - 1504 N2 - Superparamagnetic iron oxide particles (SPIO and USPIO) have a variety of applications in molecular and cellular imaging. Most of the recent research has concerned cellular imaging with imaging of in vivo macrophage activity. According to the iron oxide nanoparticle composition and size which influence their biodistribution, several clinical applications are possible: detection liver metastases, metastatic lymph nodes, inflammatory and/or degenerative diseases. USPIO are investigated as blood pool agents with T1 weighted sequence for angiography, tumour permeability and tumour blood volume or steady-state cerebral blood volume and vessel size index measurements using T2* weighted sequences. Stem cell migration and immune cell trafficking, as well as targeted iron oxide nanoparticles for molecular imaging studies, are at the stage of proof of concept, mainly in animal models. KW - molecular-imaging KW - mri KW - spio KW - uspio AU - Corot, Claire AU - Robert, Philippe AU - Idee, Jean-Marc AU - Port, Marc PY - 2006/12/01/ UR - http://dx.doi.org/10.1016/j.addr.2006.09.013 ER -