Determination of the MRI contrast agent concentration time course in vivo following bolus injection: effect of equilibrium transcytolemmal water exchange.

@article{citeulike:2066059, abstract = {For bolus-tracking studies, it is commonly assumed that CR concentration bears a linear relationship with the measured (usually longitudinal) (1)H(2)O relaxation rate constant, R*(1) identical with(T(1) *)(-1). This requires that equilibrium transcytolemmal water exchange be in the fast exchange limit (FXL). However, though systems remain in fast exchange, the FXL will not usually obtain. Here, the consequences are considered: 1) the measurement of R(1) * itself can be affected, 2) the resultant non-linear [CR]-dependence causes significant error by assuming FXL, 3) the thermodynamic [CR] (based on the space in which CR is actually distributed) can be determined, 4) transcytolemmal water permeability may be estimated, and 5) the pharmacokinetic parameters can be factored. For a 30-sec, 0.17 mmol/kg dose of GdDTPA(2-), the FXL assumption underestimates the [CR] maximum in rat thigh muscle by a factor of almost two. Similar results are obtained for a rat brain GS-9L gliosarcoma tumor model.}, address = {Chemistry Department, Brookhaven National Laboratory, Upton, NY 11973, USA.}, author = {Landis, C. S. and Li, X. and Telang, F. W. and Coderre, J. A. and Micca, P. L. and Rooney, W. D. and Latour, L. L. and V\'{e}tek, G. and P\'{a}lyka, I. and Springer, C. S. }, citeulike-article-id = {2066059}, issn = {0740-3194}, journal = {Magn Reson Med}, keywords = {contrast-agent, mri, transcytolemmal-water-exchange}, month = {October}, number = {4}, pages = {563--574}, posted-at = {2007-12-06 09:38:47}, priority = {4}, title = {Determination of the MRI contrast agent concentration time course in vivo following bolus injection: effect of equilibrium transcytolemmal water exchange.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/11025512}, volume = {44}, year = {2000} }

TY - JOUR ID - citeulike:2066059 L3 - citeulike-article-id:2066059 TI - Determination of the MRI contrast agent concentration time course in vivo following bolus injection: effect of equilibrium transcytolemmal water exchange. JF - Magn Reson Med VL - 44 IS - 4 SP - 563 EP - 574 AD - Chemistry Department, Brookhaven National Laboratory, Upton, NY 11973, USA. SN - 0740-3194 N2 - For bolus-tracking studies, it is commonly assumed that CR concentration bears a linear relationship with the measured (usually longitudinal) (1)H(2)O relaxation rate constant, R*(1) identical with(T(1) *)(-1). This requires that equilibrium transcytolemmal water exchange be in the fast exchange limit (FXL). However, though systems remain in fast exchange, the FXL will not usually obtain. Here, the consequences are considered: 1) the measurement of R(1) * itself can be affected, 2) the resultant non-linear [CR]-dependence causes significant error by assuming FXL, 3) the thermodynamic [CR] (based on the space in which CR is actually distributed) can be determined, 4) transcytolemmal water permeability may be estimated, and 5) the pharmacokinetic parameters can be factored. For a 30-sec, 0.17 mmol/kg dose of GdDTPA(2-), the FXL assumption underestimates the [CR] maximum in rat thigh muscle by a factor of almost two. Similar results are obtained for a rat brain GS-9L gliosarcoma tumor model. KW - contrast-agent KW - mri KW - transcytolemmal-water-exchange AU - Landis, CS AU - Li, X AU - Telang, FW AU - Coderre, JA AU - Micca, PL AU - Rooney, WD AU - Latour, LL AU - Vétek, G AU - Pályka, I AU - Springer, CS PY - 2000/10// UR - http://view.ncbi.nlm.nih.gov/pubmed/11025512 ER -