High field gradient targeting of magnetic nanoparticle-loaded endothelial cells to the surfaces of steel stents

@article{citeulike:2236570, abstract = {A cell delivery strategy was investigated that was hypothesized to enable magnetic targeting of endothelial cells to the steel surfaces of intraarterial stents because of the following mechanisms: (i) preloading cells with biodegradable polymeric superparamagnetic nanoparticles (MNPs), thereby rendering the cells magnetically responsive; and (ii) the induction of both magnetic field gradients around the wires of a steel stent and magnetic moments within MNPs because of a uniform external magnetic field, thereby targeting MNP-laden cells to the stent wires. In vitro studies demonstrated that MNP-loaded bovine aortic endothelial cells (BAECs) could be magnetically targeted to steel stent wires. In vivo MNP-loaded BAECs transduced with adenoviruses expressing luciferase (Luc) were targeted to stents deployed in rat carotid arteries in the presence of a uniform magnetic field with significantly greater Luc expression, detected by in vivo optical imaging, than nonmagnetic controls. 10.1073/pnas.0708338105}, author = {Polyak, Boris and Fishbein, Ilia and Chorny, Michael and Alferiev, Ivan and Williams, Darryl and Yellen, Ben and Friedman, Gary and Levy, Robert J. }, citeulike-article-id = {2236570}, doi = {10.1073/pnas.0708338105}, journal = {Proceedings of the National Academy of Sciences}, keywords = {endothelial\_cell, magnetic, medical\_science}, month = {January}, number = {2}, pages = {698--703}, posted-at = {2008-01-15 22:40:22}, priority = {4}, title = {High field gradient targeting of magnetic nanoparticle-loaded endothelial cells to the surfaces of steel stents}, url = {http://dx.doi.org/10.1073/pnas.0708338105}, volume = {105}, year = {2008} }

TY - JOUR ID - citeulike:2236570 L3 - citeulike-article-id:2236570 TI - High field gradient targeting of magnetic nanoparticle-loaded endothelial cells to the surfaces of steel stents JF - Proceedings of the National Academy of Sciences VL - 105 IS - 2 SP - 698 EP - 703 N2 - A cell delivery strategy was investigated that was hypothesized to enable magnetic targeting of endothelial cells to the steel surfaces of intraarterial stents because of the following mechanisms: (i) preloading cells with biodegradable polymeric superparamagnetic nanoparticles (MNPs), thereby rendering the cells magnetically responsive; and (ii) the induction of both magnetic field gradients around the wires of a steel stent and magnetic moments within MNPs because of a uniform external magnetic field, thereby targeting MNP-laden cells to the stent wires. In vitro studies demonstrated that MNP-loaded bovine aortic endothelial cells (BAECs) could be magnetically targeted to steel stent wires. In vivo MNP-loaded BAECs transduced with adenoviruses expressing luciferase (Luc) were targeted to stents deployed in rat carotid arteries in the presence of a uniform magnetic field with significantly greater Luc expression, detected by in vivo optical imaging, than nonmagnetic controls. 10.1073/pnas.0708338105 KW - endothelial_cell KW - magnetic KW - medical_science AU - Polyak, Boris AU - Fishbein, Ilia AU - Chorny, Michael AU - Alferiev, Ivan AU - Williams, Darryl AU - Yellen, Ben AU - Friedman, Gary AU - Levy, Robert PY - 2008/01/15/ UR - http://dx.doi.org/10.1073/pnas.0708338105 ER -