Characterisation of grafted supports used for solid-phase synthesis

@article{citeulike:1689402, abstract = {A series of ?pellicular? type supports were fabricated by direct gamma-radiation-mediated graft polymerisation of styrene onto polypropylene, followed by aminomethylation. Raman spectroscopy was used for measuring the level of penetration of polystyrene graft into polypropylene, and other structural features such as density of graft and depth of functionalisation. The kinetics of the coupling of fluorenylmethylcarbamate (Fmoc)-labelled amino acids, to the aminomethylated polystyrene grafts have been measured by UV absorption followed cleavage of the Fmoc chromophore. The Raman spectroscopy results showed that for this series of experiments the calculated rate coefficient for coupling of Fmoc-labelled amino acids was primarily dependent on graft thickness, but was also influenced by the proportion of polystyrene graft to polypropylene. In general, it was also shown that with increasing loading capacity of support the calculated rate coefficient for amino-acid coupling decreased correspondingly. In addition, a support that had both a high rate coefficient and a high loading capacity was prepared from polypropylene base material with a co-continuous porous structure (high surface area). Copyright {\copyright} 2003 Society of Chemical Industry}, address = {Polymerat Pty Ltd, Unit 4, 26 Brandl Street, Brisbane Technology Park, Eight Mile Plains, Queensland 4113, Australia}, author = {Blakey, Idriss and Day, Gary and Girjes, Ebtihal and Hunter, David S. and Rasoul, Firas }, citeulike-article-id = {1689402}, doi = {http://dx.doi.org/10.1002/pi.1300}, journal = {Polymer International}, keywords = {pp, raman, solid, support}, number = {11}, pages = {1734--1739}, posted-at = {2007-09-24 13:37:48}, priority = {5}, title = {Characterisation of grafted supports used for solid-phase synthesis}, url = {http://dx.doi.org/10.1002/pi.1300}, volume = {52}, year = {2003} }

TY - JOUR ID - citeulike:1689402 L3 - citeulike-article-id:1689402 TI - Characterisation of grafted supports used for solid-phase synthesis JF - Polymer International VL - 52 IS - 11 SP - 1734 EP - 1739 AD - Polymerat Pty Ltd, Unit 4, 26 Brandl Street, Brisbane Technology Park, Eight Mile Plains, Queensland 4113, Australia N2 - A series of ?pellicular? type supports were fabricated by direct gamma-radiation-mediated graft polymerisation of styrene onto polypropylene, followed by aminomethylation. Raman spectroscopy was used for measuring the level of penetration of polystyrene graft into polypropylene, and other structural features such as density of graft and depth of functionalisation. The kinetics of the coupling of fluorenylmethylcarbamate (Fmoc)-labelled amino acids, to the aminomethylated polystyrene grafts have been measured by UV absorption followed cleavage of the Fmoc chromophore. The Raman spectroscopy results showed that for this series of experiments the calculated rate coefficient for coupling of Fmoc-labelled amino acids was primarily dependent on graft thickness, but was also influenced by the proportion of polystyrene graft to polypropylene. In general, it was also shown that with increasing loading capacity of support the calculated rate coefficient for amino-acid coupling decreased correspondingly. In addition, a support that had both a high rate coefficient and a high loading capacity was prepared from polypropylene base material with a co-continuous porous structure (high surface area). Copyright © 2003 Society of Chemical Industry KW - pp KW - raman KW - solid KW - support AU - Blakey, Idriss AU - Day, Gary AU - Girjes, Ebtihal AU - Hunter, David AU - Rasoul, Firas PY - 2003/// UR - http://dx.doi.org/10.1002/pi.1300 ER -