[Novel chiroptical methods in pharmaceutical analysis]

@article{citeulike:2449704, abstract = {Chiroptical spectroscopy, and its double and triple hyphenated combinations with UV-VIS spectroscopy and/or separation techniques constitute great progress in pharmaceutical analysis, of which five recently developed methods are surveyed here, as follows: The determination of enantiomeric purity by double, CD/UV detection without, and with the latter one provides enhanced sensitivity and selectivity. The determination of chromatographic peak homogeneity, by double detection, and peak slicing by recording. The separation, identification and four stereoisomers of doubly chiral compounds, by HPLC separation on chiral column, and optical-chiroptical detection.}, address = {SOTE Gy\'{o}gyszer\'{e}szi K\'{e}miai Int\'{e}zet, Budapest.}, author = {Gergely, A. and Heged\'{u}s, H. and Horv\'{a}th, P. and Nosz\'{a}l, B. and Sz\'{a}sz, G. and Zsila, F. }, citeulike-article-id = {2449704}, issn = {0001-6659}, journal = {Acta Pharm Hung}, month = {June}, number = {3}, pages = {128--134}, posted-at = {2008-03-01 00:42:42}, priority = {0}, title = {[Novel chiroptical methods in pharmaceutical analysis]}, url = {http://view.ncbi.nlm.nih.gov/pubmed/10401156}, volume = {69}, year = {1999} }

TY - JOUR ID - citeulike:2449704 L3 - citeulike-article-id:2449704 TI - [Novel chiroptical methods in pharmaceutical analysis] JF - Acta Pharm Hung VL - 69 IS - 3 SP - 128 EP - 134 AD - SOTE Gyógyszerészi Kémiai Intézet, Budapest. SN - 0001-6659 N2 - Chiroptical spectroscopy, and its double and triple hyphenated combinations with UV-VIS spectroscopy and/or separation techniques constitute great progress in pharmaceutical analysis, of which five recently developed methods are surveyed here, as follows: The determination of enantiomeric purity by double, CD/UV detection without, and with the latter one provides enhanced sensitivity and selectivity. The determination of chromatographic peak homogeneity, by double detection, and peak slicing by recording. The separation, identification and four stereoisomers of doubly chiral compounds, by HPLC separation on chiral column, and optical-chiroptical detection. AU - Gergely, A AU - Hegedús, H AU - Horváth, P AU - Noszál, B AU - Szász, G AU - Zsila, F PY - 1999/06// UR - http://view.ncbi.nlm.nih.gov/pubmed/10401156 ER -