Determination of absolute configuration of ketamine enantiomers by HPLC-CD-UV technique.

by: A Gergely, F Zsila, P Horváth, G Szász

Chirality, Vol. 11, No. 10. (1999), pp. 741-744.

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Abstract

Recognizing that the stereochemical structure of NMDA receptor antagonist ketamine provides valuable data about the relationship between its conformation and absolute configuration by CD-UV analysis, a method for the identification of ketamine enantiomers is proposed which avoids the need for authentic samples of the enantiomers. The ketamine enantiomers were separated by HPLC using Chiralcel OJ stationary phase. The in situ registration of CD and UV spectra, together with the application of the octant rule for cyclohexanone derivatives, makes possible the direct assignment of the eluted ketamine enantiomers.

@article{citeulike:2449706, abstract = {Recognizing that the stereochemical structure of NMDA receptor antagonist ketamine provides valuable data about the relationship between its conformation and absolute configuration by CD-UV analysis, a method for the identification of ketamine enantiomers is proposed which avoids the need for authentic samples of the enantiomers. The ketamine enantiomers were separated by HPLC using Chiralcel OJ stationary phase. The in situ registration of CD and UV spectra, together with the application of the octant rule for cyclohexanone derivatives, makes possible the direct assignment of the eluted ketamine enantiomers.}, address = {Institute of Pharmaceutical Chemistry, Semmelweis University of Medicine, H\"{o}gyes Endre u. 9. Budapest, H-1092, Hungary. GERAND@HOGYES.SOTE.HU}, author = {Gergely, A. and Zsila, F. and Horv\'{a}th, P. and Sz\'{a}sz, G. }, citeulike-article-id = {2449706}, doi = {10.1002/(SICI)1520-636X(1999)11:10\<741::AID-CHIR1\>3.0.CO;2-2}, issn = {0899-0042}, journal = {Chirality}, number = {10}, pages = {741--744}, posted-at = {2008-03-01 00:43:11}, priority = {0}, title = {Determination of absolute configuration of ketamine enantiomers by HPLC-CD-UV technique.}, url = {http://dx.doi.org/10.1002/(SICI)1520-636X(1999)11:10\<741::AID-CHIR1\>3.0.CO;2-2}, volume = {11}, year = {1999} }

RIS record

TY - JOUR ID - citeulike:2449706 L3 - citeulike-article-id:2449706 TI - Determination of absolute configuration of ketamine enantiomers by HPLC-CD-UV technique. JF - Chirality VL - 11 IS - 10 SP - 741 EP - 744 AD - Institute of Pharmaceutical Chemistry, Semmelweis University of Medicine, Högyes Endre u. 9. Budapest, H-1092, Hungary. GERAND@HOGYES.SOTE.HU SN - 0899-0042 N2 - Recognizing that the stereochemical structure of NMDA receptor antagonist ketamine provides valuable data about the relationship between its conformation and absolute configuration by CD-UV analysis, a method for the identification of ketamine enantiomers is proposed which avoids the need for authentic samples of the enantiomers. The ketamine enantiomers were separated by HPLC using Chiralcel OJ stationary phase. The in situ registration of CD and UV spectra, together with the application of the octant rule for cyclohexanone derivatives, makes possible the direct assignment of the eluted ketamine enantiomers. AU - Gergely, A AU - Zsila, F AU - Horváth, P AU - Szász, G PY - 1999/// UR - http://dx.doi.org/10.1002/(SICI)1520-636X(1999)11:10<741::AID-CHIR1>3.0.CO;2-2 ER -

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