Genome instability: a mechanistic view of its causes and consequences.

@article{citeulike:2318829, abstract = {Genomic instability in the form of mutations and chromosome rearrangements is usually associated with pathological disorders, and yet it is also crucial for evolution. Two types of elements have a key role in instability leading to rearrangements: those that act in trans to prevent instability - among them are replication, repair and S-phase checkpoint factors - and those that act in cis - chromosomal hotspots of instability such as fragile sites and highly transcribed DNA sequences. Taking these elements as a guide, we review the causes and consequences of instability with the aim of providing a mechanistic perspective on the origin of genomic instability.}, address = {Centro Andaluz de Biologia Molecular y Medicina Regenerativa CABIMER, Universidad de Sevilla-CSIC, Avd. Am\'{e}rico Vespucio s/n, 41092 Sevilla, Spain.}, author = {Aguilera, Andr\'{e}s and G\'{o}mez-Gonz\'{a}lez, Bel\'{e}n }, citeulike-article-id = {2318829}, doi = {http://dx.doi.org/10.1038/nrg2268}, issn = {1471-0064}, journal = {Nat Rev Genet}, keywords = {genome, mutation, sequence}, month = {January}, posted-at = {2008-02-19 01:22:05}, priority = {2}, title = {Genome instability: a mechanistic view of its causes and consequences.}, url = {http://dx.doi.org/10.1038/nrg2268}, year = {2008} }

TY - JOUR ID - citeulike:2318829 L3 - citeulike-article-id:2318829 TI - Genome instability: a mechanistic view of its causes and consequences. JF - Nat Rev Genet AD - Centro Andaluz de Biologia Molecular y Medicina Regenerativa CABIMER, Universidad de Sevilla-CSIC, Avd. Américo Vespucio s/n, 41092 Sevilla, Spain. SN - 1471-0064 N2 - Genomic instability in the form of mutations and chromosome rearrangements is usually associated with pathological disorders, and yet it is also crucial for evolution. Two types of elements have a key role in instability leading to rearrangements: those that act in trans to prevent instability - among them are replication, repair and S-phase checkpoint factors - and those that act in cis - chromosomal hotspots of instability such as fragile sites and highly transcribed DNA sequences. Taking these elements as a guide, we review the causes and consequences of instability with the aim of providing a mechanistic perspective on the origin of genomic instability. KW - genome KW - mutation KW - sequence AU - Aguilera, Andrés AU - Gómez-González, Belén PY - 2008/01/29/ UR - http://dx.doi.org/10.1038/nrg2268 ER -